PF3D7_1200600 (VAR2CSA)

Aliases : VAR2CSA

Description : SSF140924: No description available. Pfam domain(s): PF03011: PFEMP DBL domain, PF15445: "acidic terminal segments, variant surface antigen of PfEMP1", PF15448: N-terminal segments of P. falciparum erythrocyte membrane protein, PF05424: Duffy binding domain.

Gene families : OG_01_0000012 (Orthofinderv1.1.8) Phylogenetic Tree(s): OG0000012_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	Pfa RNA-seq: PF3D7_1200600
Cluster	P. falciparum: Cluster_16

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	None	Extended
MF	GO:0005539	glycosaminoglycan binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0009405	pathogenesis	IEA	Interproscan predictions
BP	GO:0009405	pathogenesis	IEA	PlasmoDB
BP	GO:0009605	response to external stimulus	None	Extended
BP	GO:0009607	response to biotic stimulus	None	Extended
CC	GO:0016021	integral component of membrane	IEA	Interproscan predictions
CC	GO:0016021	integral component of membrane	IEA	PlasmoDB
CC	GO:0020002	host cell plasma membrane	TAS	PlasmoDB
BP	GO:0020013	modulation by symbiont of host erythrocyte aggregation	TAS	PlasmoDB
CC	GO:0020030	infected host cell surface knob	TAS	PlasmoDB
BP	GO:0020033	antigenic variation	TAS	PlasmoDB
BP	GO:0020035	cytoadherence to microvasculature, mediated by symbiont protein	IDA	PlasmoDB
BP	GO:0022407	regulation of cell-cell adhesion	None	Extended
BP	GO:0022610	biological adhesion	None	Extended
BP	GO:0030155	regulation of cell adhesion	None	Extended
CC	GO:0031224	intrinsic component of membrane	None	Extended
CC	GO:0033643	host cell part	None	Extended
CC	GO:0033644	host cell membrane	None	Extended
CC	GO:0033646	host intracellular part	None	Extended
CC	GO:0033655	host cell cytoplasm part	None	Extended
BP	GO:0034110	regulation of homotypic cell-cell adhesion	None	Extended
BP	GO:0034118	regulation of erythrocyte aggregation	None	Extended
MF	GO:0035373	chondroitin sulfate proteoglycan binding	IPI	PlasmoDB
BP	GO:0035821	modification of morphology or physiology of other organism	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043207	response to external biotic stimulus	None	Extended
MF	GO:0043394	proteoglycan binding	None	Extended
BP	GO:0044003	modification by symbiont of host morphology or physiology	None	Extended
BP	GO:0044068	modulation by symbiont of host cellular process	None	Extended
CC	GO:0044217	other organism part	None	Extended
CC	GO:0044218	other organism cell membrane	None	Extended
CC	GO:0044279	other organism membrane	None	Extended
BP	GO:0044406	adhesion of symbiont to host	None	Extended
BP	GO:0044419	interspecies interaction between organisms	None	Extended
CC	GO:0044425	membrane part	None	Extended
MF	GO:0046789	host cell surface receptor binding	IDA	PlasmoDB
MF	GO:0046789	host cell surface receptor binding	IEA	Interproscan predictions
MF	GO:0046789	host cell surface receptor binding	IEA	PlasmoDB
MF	GO:0046812	host cell surface binding	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
MF	GO:0050839	cell adhesion molecule binding	TAS	PlasmoDB
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051701	interaction with host	None	Extended
BP	GO:0051704	multi-organism process	None	Extended
BP	GO:0051707	response to other organism	None	Extended
BP	GO:0051805	evasion or tolerance of immune response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051807	evasion or tolerance of defense response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051809	passive evasion of immune response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051817	modification of morphology or physiology of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051832	avoidance of defenses of other organism involved in symbiotic interaction	None	Extended
BP	GO:0051834	evasion or tolerance of defenses of other organism involved in symbiotic interaction	None	Extended
BP	GO:0052173	response to defenses of other organism involved in symbiotic interaction	None	Extended
BP	GO:0052564	response to immune response of other organism involved in symbiotic interaction	None	Extended
BP	GO:0065007	biological regulation	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901681	sulfur compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003729	mRNA binding	IEP	Predicted GO
BP	GO:0006778	porphyrin-containing compound metabolic process	IEP	Predicted GO
BP	GO:0006787	porphyrin-containing compound catabolic process	IEP	Predicted GO
CC	GO:0020036	Maurer's cleft	IEP	Predicted GO
CC	GO:0031982	vesicle	IEP	Predicted GO
BP	GO:0033013	tetrapyrrole metabolic process	IEP	Predicted GO
BP	GO:0033015	tetrapyrrole catabolic process	IEP	Predicted GO
BP	GO:0042167	heme catabolic process	IEP	Predicted GO
BP	GO:0042168	heme metabolic process	IEP	Predicted GO
BP	GO:0042440	pigment metabolic process	IEP	Predicted GO
BP	GO:0046149	pigment catabolic process	IEP	Predicted GO
BP	GO:0051187	cofactor catabolic process	IEP	Predicted GO

InterPro domains	Description	Start	Stop
IPR008602	Duffy-antigen_binding	1253	1422
IPR008602	Duffy-antigen_binding	2365	2510
IPR008602	Duffy-antigen_binding	1603	1731
IPR008602	Duffy-antigen_binding	2030	2159
IPR008602	Duffy-antigen_binding	95	233
IPR008602	Duffy-antigen_binding	580	729
IPR029211	PfEMP1_ATS	2650	3035
IPR032761	PfEMP1_N	1	50
IPR004258	DBL	1448	1595

External Links

PlasmoDB	2277.t00006
PlasmoDB	811060
PlasmoDB	MAL12P1.6
PlasmoDB	PFL0030c

PF3D7_1200600 (VAR2CSA)

Expression Profile

Co-expression Networks

Functional Annotation